From Buffalo International Airport:

Take I-90 west towards Erie, exit 55 which is 219 south.
Holiday Valley is about 50 miles south of airport.

From the East:

Take NY Route 17 east to exit 21 in Salamanca, New York.
Go north on Route 219 for 10 miles to Ellicottville.
Holiday Valley will be on your left.

From the West:

Take Interstate 90 east to exit 10A, Route 17.
Go east to exit 21 in Salamanca, New York.
Go north on Route 219 for 10 miles to Ellicottville.
Holiday Valley will be on your left.